GEOGRAPHIC DIFFERENCES IN THE SPREAD, MORBIDITY AND MORTALITY OF COVID -19:IMPORTANT CONTRIBUTING FACTORS



The use of interim data and Data Monitoring Committee recommendations in randomized controlled trial reports: frequency, implications and potential sources of bias

Abstract Background Interim analysis of accumulating trial data is important to protect participant safety during randomized controlled trials Water Bottle Cap (RCTs).Data Monitoring Committees (DMCs) often undertake such analyses, but their widening role may lead to extended use of interim analysis or recommendations that could potentially bias tr

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